Home / Glossary Rh incompatibility By Motherly Editors April 3, 2024 Rectangle Definition Rh incompatibility is a condition that occurs during pregnancy if a woman has Rh-negative blood and her baby has Rh-positive blood. The mother’s body will produce an immune response against the baby’s blood, seeing it as a foreign substance. This can lead to the mother’s immune system attacking the baby’s red blood cells, causing anemia and other health problems in the baby. Key Takeaways Rh incompatibility refers to a scenario in pregnancy where the mother has Rh-negative blood type and the fetus has Rh-positive blood type, inherited from the father. This difference in blood types can lead to the mother’s immune system treating the fetus’s Rh-positive cells as foreign bodies, potentially leading to complications. When the mother’s immune system attacks the Rh-positive cells, it may cause Hemolytic Disease of the Newborn (HDN) in the fetus or newborn. Symptoms range from mild to severe and can include jaundice, anemia, brain damage, heart failure, or even death in the most severe cases. Rh incompatibility can be effectively managed with timely intervention. If the mother is Rh-negative, she will typically receive Rh immunoglobulin injections during her pregnancy and shortly after delivery to prevent her immune system from producing Rh antibodies that could endanger subsequent pregnancies. Importance Rh incompatibility is critically important in motherhood as it pertains to the possible conflict between the blood types of a mother and her unborn child. Specifically, it arises when a mother who has Rh-negative blood type carries a baby with Rh-positive blood type, inherited from the father. If the mother’s Rh-negative blood mixes with the baby’s Rh-positive blood, her body may react by producing antibodies against the baby’s blood, recognizing it as a foreign substance. This can lead to a condition called Hemolytic Disease of the Newborn, where the mother’s antibodies cross the placenta and destroy the baby’s red blood cells, leading to serious health problems such as jaundice, heart failure, or even death in severe cases. Therefore, understanding and managing Rh incompatibility is essential for the health of both the mother and the baby. Explanation Rh incompatibility refers to a specific interaction between the blood of a mother and her unborn baby. This situation happens when a mother’s Rh blood type (whether Rh positive or Rh negative) doesn’t match her baby’s. Understanding this condition is crucial in prenatal care because it can lead to Rh disease, also known as Rh sensitization, a condition where the mother’s immune system produces antibodies that attack and could potentially harm the baby’s blood cells. The purpose of recognizing Rh incompatibility is to identify and monitor the risk it presents and take preventive measures if necessary. If a mother is Rh-negative and the baby is Rh-positive, the mother’s body might treat the baby’s Rh-positive cells as if they were a foreign substance and produce antibodies against them. These antibodies can cross the placenta and target the baby’s red blood cells, leading to health issues like jaundice, anemia, brain damage, or even stillbirth in severe cases. However, Rh incompatibility is completely manageable with routine prenatal care, including blood tests to identify Rh factor and a treatment called Rh immune globulin to prevent the mother from developing Rh antibodies. Examples of Rh incompatibility Rh incompatibility is a condition that develops when a pregnant woman’s Rh blood type (Rhesus) is different from her unborn baby’s Rh blood type. Here are three real-world examples: A First Pregnancy: A happy first-time mother has the Rh negative blood type, while her baby has Rh positive blood type, inherited from the father. The mother’s body sees the baby’s Rh positive blood type as foreign. If the baby’s blood enters the mother’s bloodstream, which often happens during delivery, her body may produce proteins called Rh antibodies that attack Rh positive blood cells. Generally, this does not affect a first-time pregnancy but may complicate future pregnancies. In a Second Pregnancy Scenario: In her second pregnancy, if the baby is also Rh positive, the mother’s now-existing Rh antibodies may cross the placenta, attacking the baby’s red blood cells, causing severe anemia which can lead to life-threatening conditions like hydrops fetalis, kernicterus or even cause the baby to be stillborn. Cases With Treatments: A pregnant woman discovers through early prenatal screenings that she is Rh negative. She receives Rh immunoglobulin (such as RhoGAM) shots during her pregnancy and post-delivery, which prevent her immune system from producing Rh antibodies. This helps protect her future pregnancies from complications associated with Rh incompatibility.These examples illustrate Rh incompatibility and its potential consequences, as well as how medical interventions can help manage the condition to facilitate healthier pregnancies and births. Rh Incompatibility FAQ What is Rh incompatibility? Rh incompatibility is a condition that happens during pregnancy if a woman has Rh-negative blood and her baby has Rh-positive blood. Rh is a protein that most people have (Rh-positive) but some do not (Rh-negative). Rh incompatibility can cause serious health problems for the baby, especially in subsequent pregnancies. How is Rh incompatibility diagnosed? Rh incompatibility can be diagnosed through blood tests before and during pregnancy. If a pregnant woman is found to have Rh-negative blood, further tests may be done to determine if she is at risk for Rh incompatibility problems. When does Rh incompatibility become a problem? The first pregnancy often does not cause problems unless there is a reason for the baby’s and mother’s blood to mix. Problems can occur in subsequent pregnancies when the mother’s immune system produces Rh antibodies that can cross the placenta and harm the Rh-positive baby. What is the treatment for Rh incompatibility? If a pregnant woman has Rh-negative blood, she may receive Rh immunoglobulin to prevent Rh-related problems. This is usually given during the 28th week of pregnancy and within 72 hours after childbirth if the baby has Rh-positive blood. What precautions should be taken in case of Rh incompatibility? It is recommended that an Rh-negative woman and her Rh-positive partner consult with a healthcare provider before becoming pregnant. If pregnant, the woman should receive routine prenatal care, including Rh factor testing and appropriate Rh immunoglobulin treatment. Related Motherhood Terms Anti-D Immunoglobulin Rh Sensitization D blood type Indirect Coombs test Hemolytic Disease of the Newborn (HDN) Sources for More Information Mayo Clinic: It is a reliable site that provides information on diseases and conditions, including Rh incompatibility. Healthline: This site has dedicated sections for pregnancy and newborn baby care where one can find information about Rh incompatibility. WebMD: It is a trusted resource for health information, including in-depth articles about Rh incompatibility during pregnancy. Centers for Disease Control and Prevention (CDC): The CDC site provides scientific, statistical, and public health information, including data on Rh incompatibility. The latest Rh incompatibility Rh incompatibility Rh incompatibility Rh incompatibility